Tracking Down a Tonic for a Long Life (ScienceMagazine)
Scientists may not yet have found the fountain of youth, but Ye et al. now report on a screen for drugs that can extend life span in the worm Caenorhabditis elegans.
Starting with a collection of over 1200 drugs that have or are suspected to have activity in human cells, they identified nearly 60 compounds that extended life span up to 43%.
Many of the compounds targeted proteins that function in signaling pathways between cells, such as hormone or neurotransmitter receptors, particularly those for adrenaline and noradrenaline, serotonin, dopamine, histamine, and serotonin.
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A pharmacological network for lifespan extension in Caenorhabditis elegans (Global Medical Discovery)
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